Monday afternoon, September 6^th

from 16.00

Arrival and Registration

from 18.00

Dinner

Monday evening, September 6th

Chairperson:

Arnold von Eckardstein

20.00 - 20.05

Arnold von Eckardstein
Welcome

from 20.05

Stephen O’Rahilly, Cambridge
Keynote Lecture: Human obesity and insulin resistance; lessons from human genetics

Tuesday morning, September 7^th

Topic I: Metabolism and storage of triglycerides
Chairperson: Andreas Niemeier, Hamburg

8.30 - 9.10 

Ira Goldberg, New York
Lipids as fuels and lipids as toxins

9.10 - 9.30 

Alexander Bartelt, Hamburg
Activation of brown adipose tissue is a master switch for systemic triglyceride metabolism

9.30 - 9.50 

Juliane Gertrude Bogner-Strauss, Graz
Adipocyte plasma membrane-associated protein (APMAP): a transmembrane protein required for adipogenesis and targeted by PPARgamma

9.50 - 10.10 

Janna van Diepen, Leiden
Absence of the NLRP-3 inflammasome protects against the development of obesity and insulin resistance

10.10 - 10.40

Coffee Break

Tuesday morning, September 7^th

Topic II: Inflammation and hepatic steatosis
Chairperson: Monique Mulder, Rotterdam

10.40 - 11.20 

Jeffrey D. Esko, San Diego
Proteoglycans Drive Lipoprotein Clearance

11.20 - 11.40 

Jimmy J.P. Berbée, Leiden
Apolipoprotein C1 stimulates the biological response to lipopolysaccharide via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix

11.40 - 12.00 

Bart Staels, Lille
PPAR alpha gene level differently modulates lipid metabolism and inflammation in apolipoprotein E2-knock-in mice

12.00 - 12.20 

Veerle Bieghs, Maastricht
CYP27: a novel player in diet-induced NASH

12.20 - 12.40 

Ryan E. Temel, Winston Salem
ASO-mediated knockdown of ACAT2 causes regression of hepatic steatosis in mice

Tuesday afternoon, September 7^th

from 12.45

Lunch

16.00 - 18.00

Wine and Science

from 18.00

Dinner

Tuesday evening, September 7^th

Topic III: Nutrition and Energy Metabolism
Chairpersons: Rachel Fisher, Stockholm and Ernst Malle, Graz

19.30 - 20.10 

Fredrik Karpe, Oxford
Channelling of dietary fat into adipose tissue

20.10 - 20.30 

Barbara Fielding, Oxford
Evidence for tissue-specific regulation of de novo lipogenesis and desaturation of fatty acids in human adipose tissue

20.30 - 20.50 

Leanne Hodson, Oxford
Greater dietary fat oxidation in abdominally-obese compared to lean men: an adaptive mechanism to prevent liver fat accumulation?

20.50 - 21.10 

Sander Kersten, Wageningen
Angptl4 protects against severe pro-inflammatory effects of dietary saturated fat by inhibiting LPL-dependent uptake of fatty acids in mesenteric lymph node macrophages

21.10 - 21.30

Veronique Carrière, Paris
The receptor scavenger class B type 1 and the sensing of dietary lipids by enterocytes

21.30 - 21.50 

Max Nieuwdorp, Amsterdam
Metabolic effects of transplantating gut microbiota from lean donors to subjects with metabolic syndrome

Wednesday morning, September 8^th

Topic IV: Functional Genomics and Genetics
Chairpersons: Anne Tybjaerg Hansen, Copenhagen and Albert Groen, Groningen

8.30 - 9.10 

Karsten Suhre, Munich
Genetically determined metabotypes and their role in human lipid metabolism

9.10 - 9.30 

Marcel Wolfs, Groningen
A systems genetics approach reveals association between expression of immune genes in adipose tissue from obese individuals and plasma levels of HDL and glucose

9.30 - 9.50 

Pirkka-Pekka Laurila, Helsinki
HDL-associating allelic variants of F13A1 contribute to its differential expression in adipose tissue

9.50 - 10.10 

Jan-Albert Kuivenhoven, Amsterdam
Mutations in the gene encoding for polypeptide N-actetylgalactosaminyltransferase 2 (GALANT2) are associated with high levels of plasma high-density lipoprotein (HDL) cholesterol

10.10 - 10.30 

Jay Patankar, Graz
GATA4 bears a genetic risk of hyperlipidemia in humans, intestine specific GATA4 knockouts are resistant to diet induced obesity

10.30 - 11.00 

Coffee Break

11.00 - 11.20 

Stefan Stender, Copenhagen
Genetic variation in liver X receptor alpha predicts risk of ischemic vascular disease in the general population

11.20 - 11.40 

Philippa Talmud, London
Using genetics as a tool to determine if plasma triglycerides are causally related to coronary disease

11.40 - 12.00 

Stefan Coassin, Innsbruck
Investigation and functional characterization of common and rare genetic variation of the ATGL lipase in a large healthy working population

12.00  - 12.20

Jorie Versmissen, Rotterdam
Low-density lipoprotein receptor mutations protect against increased risk of coronary heart disease by Apolipoprotein isoform E4

12.20 - 12.40

Steve Humphries, London
The combined genotype for 21 common LDL-raising variants in associated with future lipid-lowering drug usage and CHD risk

from 12.45

Lunch

Wednesday afternoon, September 8^th

Topic V: Therapeutic approaches to dyslipidemia and atherosclerosis

Chairperson: Franco Bernini, Parma

14.00 - 14.40 

Eric J. Niesor, Basel
HDL as a therapeutic target

14.40 - 15.00 

Louis Havekes, Leiden
Role of CETP in the HDL-increasing effects of hypolipidemic drugs

15.00 - 15.20   

Bo Angelin, Stockholm
Induction of local thyreotoxicosis in the liver: Experience with eprotirome

15.20 - 15.40 

Paolo Parini, Stockholm
Effects of atorvastatin on the human hepatic expression of genes regulating carbohydrate and triglyceride metabolism

15.40 - 16.10

Coffee Break

Wednesday afternoon, September 8^th

Topic VI: Lipoprotein metabolism Part I: HDL and Reverse Cholesterol Transport
Chairperson: Paolo Parini, Stockholm

16.10 - 16.50 

John Parks, Winston Salem
The role of hepatic ABCA1 in lipoprotein metabolism

16.50 - 17.10 

Onno G. Holleboom, Amsterdam
In vivo tissue cholesterol efflux is impaired in carriers of mutations in APOA1 and ABCA1

17.10 - 17.30 

Gemma Brufau, Groningen
Plant sterol supplementation increases transintestinal cholesterol excretion in mice via ABCG5

17.30  - 17.50

Arnold von Eckardstein, Zurich
Monogenic disorders of HDL metabolism are associated with distinct changes in the lipidome of plasma and lipoproteins

from 18.30

Social Event

Thursday morning, September 9^th

Topic VII: Lipoproteins Part II: ApoB containing lipoproteins
Chairperson: Athina Kalopissis, Paris

9.00 - 9.20 

Andrea Wagner, Graz
The importance of the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) for chylomicron biosynthesis and secretion

9.20 - 9.40 

Christina Christoffersen, Copenhagen
Opposing effects of apoM on catabolism of apoB-containing lipoproteins and atherosclerosis

9.40 - 10.00

Lena Persson, Stockholm
Circulating PCSK9 displays a pronounced diurnal regulation that parallels hepatic cholesterol synthesis in humans

10.00 - 10.20 

Terhi Vihervaara, Helsinki
Sterol binding by OSBP-related protein 1L (ORP1L) regulates late endosome dynamics and function

10.20  - 10.40

Coffee Break

10.40 - 11.00 

Young Investigator Awards

Thursday morning, September 9^th

Topic VIII: Varia
Chairperson: Dilys Freeman, Glasgow

11.00 - 11.20 

Wolfgang Schneider, Vienna
Biological roles of the shed soluble form of LR11/sorLA

11.20 - 11.40 

Dagmar Kratky, Graz
DGAT1 deficiency attenuates atherosclerotic lesion development in ApoE knockout mice

11.40 - 12.00 

Laura Calabresi, Milano
Endothelial function in genetic LCAT deficiency

12.00 – 12.20 

Ruth Frikke-Schmidt, Copenhagen
Serum sCD163 from macrophages predicts risk of type 2 diabetes in the general population

From 12.00

Farewell, Lunch, Departure